Research

Suntheanine® L-Theanine Research/Studies

In search of a safe natural sleep aid
Published: 2015
Author: Rao, T.P
Publication: Journal of the American College of Nutrition. March, 16, 2015
Read Full Study: http://www.ncbi.nlm.nih.gov

Effect of L-theanine on sensorimotor gating in healthy human subjects
Published: 2013
Author: Ota, M.
Publication: Psychiatry and Clinical Neurosciences 2013.
Read Full Study: http://www.ncbi.nlm.nih.gov

Anti-stress effect of theanine on students during pharmacy practice: Positive correlation among salivary α-amylase activity, trait anxiety and subjective stress
Published: 2013
Author: Unno, K.
Publication: Pharmacology, Biochemistry and Behavior 111 (2013) 128-135
Read Full Study: www.ncbi.nlm.nih.gov

Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses
Published: 2012
Author: Yoto, A.
Publication: Journal of Physiological Anthropology 2012, 31:28
Read Full Study: www.ncbi.nlm.nih.gov

Kinetics of L-Theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanine via capsules and green tea
Published: 2012
Author: Scheid, L.
Publication: Journal of Nutrition. October 2012, 2091 – 2096.
Read Full Study: http://www.ncbi.nlm.nih.gov

Kinetics of L-Theanine uptake and metabolism in healthy participants are comparable and after ingestion of L-Theanine via Capsules and green tea
Published: 2012
Author: Scheid, K.
Publication: J.Nutr. 142: 2091-2096, 2012.
Read Full Study: http://www.ncbi.nlm.nih.gov/pubmed/23096008

L-Theanine extends lifespan of adult Caenorhabditis elegans
Published: 2012
Author: Zarse, K.
Publication: Eur J Nutr (2012) 51:765–768
Read Full Study: www.ncbi.nlm.nih.gov

The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial
Published: 2011
Author: Lyon M.R.
Publication: Altern Med Rev. 2011 Dec
Read Full Study: http://www.ncbi.nlm.nih.gov/pubmed/22214254

Effects of L-Theanine on Attention and Reaction Time Response
Published: 2011
Author: Higashiyama, A.
Publication: . Journal of Functional Foods 2010
Read Full Study: http://www.sciencedirect.com

Effects of L-theanine on attention and reaction time response
Published: 2011
Author: A. Higashiyama
Publication: Journal of Functional Foods. 2011 May
Read Full Study: www.nutraingredients.com

Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioral depression that are induced by chronic psychosocial stress in mice
Published: 2011
Author: Unno, K.
Publication: Free Radical Research, August 2011; 45(8): 966–974
Read Full Study: http://www.ncbi.nlm.nih.gov

Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial
Published: 2011
Author: Matsumoto, K
Publication: BMC Complement Altern Med. 2011 Feb 21
Read Full Study: www.ncbi.nlm.nih.gov

A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study
Published: 2011
Author: Park, SK
Publication: J Med Food. 2011 Apr
Read Full Study: www.ncbi.nlm.nih.gov

L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study
Published: 2010
Author: Ritsner, MS
Publication: J Clin Psychiatry, November 2010.
Read Full Study: www.ncbi.nlm.nih.gov

Human disposition of L-theanine in tea or aqueous solution
Published: 2010
Author: Pijl, PC.
Publication: Journal of Functional Foods (2010) 239 – 244.
Read Full Study: http://www.sciencedirect.com

Cystine and theanine supplementation restores high-intensity resistance exercise-induced attenuation of natural killer cell activity in well-trained men
Published: 2010
Author: Kawada, S.
Publication: J Strength and Conditioning Research, 24(3): 846-851, 2010.
Read Full Study: http://www.ncbi.nlm.nih.gov

Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells
Published: 2009
Author: Liu, Q.
Publication: Cytotecnology (2009) 59:211-217.
Read Full Study: http://www.ncbi.nlm.nih.gov

L-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways
Published: 2009
Author: Kim, T.
Publication: Free Radic Biol Med. 2009 Dec 1;47(11):1601-10.
Read Full Study: http://www.ncbi.nlm.nih.gov

Effects of oral supplementation with cystine and theanine on the immune function of athletes in endurance exercise: randomized, double-blind, placebo-controlled trial
Published: 2009
Author: Murakami, S.
Publication: Biosci Biotechnol BIochem 2009 Apr 23;73(4):817-21.
Read Full Study: http://www.ncbi.nlm.nih.gov

Standardized capsule of Camellia sinensis lowers cardiovascular risk factors in a randomized, double-blind, placebo-controlled study
Published: 2009
Author: Nantz MP
Publication: Nutrition. February 2009
Read Full Study: www.ncbi.nlm.nih.gov

The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task
Published: 2009
Author: Gomez-Ramirez M
Publication: Brain Topography. June 2009
Read Full Study: http://www.ncbi.nlm.nih.gov/pubmed/18841456

L-Theanine elicits an umami taste with inosine 5′-monophosphate
Published: 2008
Author: Narukawa, M.
Publication: Biosci. biotechnol. Biochem, 72 (11), 3015-3017,2008
Read Full Study: www.ncbi.nlm.nih.gov

Standardized capsule of camellia sinensis lowers cardiovascular risk factors in a randomized, double-blind, placebo-controlled study
Published: 2008
Author: Nantz P
Publication: Meri.et al./Nutrition (2008)
Read Full Study: www.ncbi.nlm.nih.gov

L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance
Published: 2008
Author: Kelley S.
Publication: Journal of Nutrition, Vol 138, No.8, August 2008.
Read Full Article: www.ncbi.nlm.nih.gov

The combined effects of L-theanine and caffeine on cognitive performance and mood
Published: 2008
Author: Owen, G.
Publication: Nutr.Neurosci. Vol. 11, No.4, August 2008.
Read Full Study: www.ncbi.nlm.nih.gov

L-theanine, a natural constituent in tea, and its effect on mental state in humans
Published: 2008
Author: Nobre, A
Publication: Asia Pac J Clin Nutr., Vol 17, 2008
Read Full Study: http://www.ncbi.nlm.nih.gov/pubmed/18296328

Theanine, an ingredient of green tea, inhibits Glutamine transport in neurons and astroglia in rat brain
Published: 2008
Author: Kakuda, T.
Publication: Journal of Neuroscience Research 86:1846-1856 (2008)
Read Full Study: www.ncbi.nlm.nih.gov

Altered levels of oxidation and phospholipase C isozyme expression in the brains of theanine-administered rats
Published: 2008
Author: Nishida K.
Publication: Biol Pharm Bull, Vol 31, No 5, May 2008
Read Full Study: www.ncbi.nlm.nih.gov

Effects of L-theanine, a unique amino Acid in tea leaves, on memory
Published: 2008
Author: Yamada, T.
Publication: Biosci Biotechnol Biochem, Vol 72, No 5, May 2008
Read Full Study: www.ncbi.nlm.nih.gov

Administration of L-theanine, a unique amino acid in tea leaves, changed feeding-relating components in serum and feeding behavior in rats
Published: 2008
Author: Yamada, T.
Publication: Biosci Biotech Biochem, 2008 May; 72(5): 1352-5
Read Full Study: http://www.ncbi.nlm.nih.gov

Effects of L-theanine, a unique amino Acid in tea leaves, on memory in a rat behavioral test
Published: 2008
Author: Yamada, T.
Publication: Biosci Biotechnol Biochem, Vol 72, No 5, May 2008
Read Full Study: http://www.ncbi.nlm.nih.gov

Efficacy (against premenstrual syndrome) and short term safety of L-theanine in a randomized, double-blind, parallel-group study in humans
Published: 2008
Author: Timmcke, J.
Publication: The FASEB Journal. 2008; 22:lb760
Read Full Study: www.fasebj.org

Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death
Published: 2008
Author: Cho H.S.
Publication: NeuroToxicology 656-662 (2008)
Read Full Study: www.ncbi.nlm.nih.gov

Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together
Published: 2008
Author: Rogers, P.J.
Publication: Psychopharmacology, Vol 195, 4, pp 569-577, Jan 2008.
Read Full Study: www.ncbi.nlm.nih.gov

The effects of L-theanine, caffeine and their combination on cognition and mood
Published: 2008
Author: Haskell, C.F
Publication: Biol Psychol, Vol 77, 2, pp 113-22, Feb 2008
Read Full Study: www.ncbi.nlm.nih.gov

L-theanine intervention enhances human lymphocyte function
Published: 2008
Author: Bukowski, J.
Publication: Nutritional Reviews Vol. 66(2); 96-102, 2008
Read Full Study: www.ncbi.nlm.nih.gov

L-theanine intervention enhances human gamma delta T lymphocyte function
Published: 2008
Author: Bukowski, J.
Publication: Nutr Rev, Vol 66, 2, pp 96-102. Feb 2008
Read Full Study: www.ncbi.nlm.nih.gov

Psychological effects of dietary components of tea: caffeine and L-theanine
Published: 2008
Author: Bryan, J.
Publication: Nutr Rev, Vol 66, 2, pp 82-90. Feb 2008
Read Full Study: www.ncbi.nlm.nih.gov

L-theanine prevents memory impairment induced by repeated cerebral ischemia in rats
Published: 2008
Author: Egashira, N.
Publication: Phytother Res, Vol 22, 1, pp 65-8, Jan 2008.
Read Full Study: www.ncbi.nlm.nih.gov

L-Theanine, gamma-glutamylethylamide, a unique amino acid leaves, modulates neurotransmitter concentrations in striatum interstitium in conscious rats
Published: 2008
Author: Yamada, T.
Publication: Amino Acids 2009 36:21-27
Read Full Study: http://www.ncbi.nlm.nih.gov

Bioactive food components that enhance γδT Cell function may play a role in cancer prevention
Published: 2008
Author: Percival, S.
Publication: Journal of Nutrition, Vol 138, 1, pp 1- 4, 2008
Read Full Study: http://jn.nutrition.org

Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine
Published: 2007
Author: Kurihara, S.
Publication: Journal of Veterinary Medical Science, Vol 69, 12, pp 1263. 2007
Read Full Study: http://www.ncbi.nlm.nih.gov

Specific Formulation of Camellia sinensis Prevents Cold and Flu Symptoms and Enhances γδ T Cell Function: A Randomized, Double-Blind, Placebo-Controlled Study
Published: 2007
Author: Cheryl A. Rowe, PhD
Publication: Journal of the American College of Nutrition, Vol. 26 No. 5, 445-452 (2007)
Read Full Study: www.ncbi.nlm.nih.gov

L-theanine, r-glutamylethylamide, increases neurotransmission concentrations and neurotrophin mRNA levels in the brain during lactation
Published: 2007
Author: Yamada, T.
Publication: Life Sciences. Vol 81, 16, pp 1247-1255. 2007
Read Full Study: www.ncbi.nlm.nih.gov

Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice
Published: 2007
Author: Egashira, N.
Publication: Journal of Pharmacological Sciences. 105, 211-214, 2007.
Read Full Study: http://www.ncbi.nlm.nih.gov

Theogallin and L-theanine as active ingredients in decaffeinated green tea extract, characterization in the freely moving rat by means of quantitative field potential analysis
Published: 2007
Author: Dimpfel, W.
Publication: Journal of Pharmacy and Pharmacology, Vol 59, 10, pp 1397. Oct 2007
Read Full Study: http://www.ncbi.nlm.nih.gov

Combined effects of L-theanine and caffeine on cognition and mood
Published: 2007
Author: Parnell, H.
Publication: Appetite London 2006, Vol 47, No 2, page 273.
Read Full Study: http://www.ncbi.nlm.nih.gov

Use of L-theanine tablets and behaviour modification for treatment of phobias in dogs: A preliminary study
Published: 2007
Author: Berteselli, G.V.
Publication: Abstract – Journal of Veterinary Behavior, Vol 2, No 3, May/June 2007
Read Full Study: http://www.journalvetbehavior.com

Clinical Efficacy of L-theanine tablets to reduce anxiety-related emotional disorders in cats: A pilot open-label clinical trial
Published: 2007
Author: Dramard, V.
Publication: Abstract – Journal of Veterinary Behavior, Vol 2, No 3, May/June 2007
Read Full Study: http://www.journalvetbehavior.com

The deployment of intersensory selective attention: a high-density electrical mapping study of the effects of theanine
Published: 2007
Author: Ramirez M,
Publication: Clinical Neuropharmacology 2007, Vol 30, No. 1, pp 25 – 38.
Read Full Study: http://www.ncbi.nlm.nih.gov/pubmed/17272967

L-theanine reduces psychological and physiological stress responses
Published: 2006
Author: Kimura, K.
Publication: Biol Psychol, Aug 21 2006.
Read Full Study: http://www.ncbi.nlm.nih.gov/pubmed/16930802

Factors that Affect the Body’s Nervous System: Relaxation Effects of Suntheanine®
Published: 2006
Author: Ozeki, M.
Publication: Nutraceutical Proteins and Peptides in Health and Disease, CRC Press, 2006, pp 377-390.
Read Full Study: www.crcpress.com

The neuropharmacology of L-Theanine (N-Ethyl-L-Glutamine): A possible neuroprotective and cognitive enhancing agent
Published: 2006
Author: Nathan, P.
Publication: Journal of Herbal Pharmacotherapy 2006, Vol 6(2) pp 21-30.
Read Full Study: http://www.ncbi.nlm.nih.gov

Pharmacology and therapeutic uses of L-theanine
Published: 2006
Author: Eschenauer, G.
Publication: American J. Health-Syst Pharm, Vol 63, Jan 1, 2006.
Read Full Study: www.ncbi.nlm.nih.gov

Effects of Suntheanine® on alcohol metabolism and hepatic toxicity
Published: 2005
Author: Sadzuka, Y.
Publication: Biol Phar. Bull., Vol 28, No 9, September 2005.
Read Full Study: www.ncbi.nlm.nih.gov

Effects of Suntheanine® on neurotransmitter release and its relationship with glutamic acid neurotransmission
Published: 2005
Author: Yamada T.
Publication: Nutritional Neuroscience, August 2005, 219-226.
Read Full Study: www.ncbi.nlm.nih.gov

Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission
Published: 2005
Author: Min, Li.
Publication: Nutritional Neuroscience, August 2005; 8(4): 219-226.
Read Full Study: http://en.cnki.com.cn

Effect of Suntheanine® on bodyweight and fat accumulation in mice
Published: 2005
Author: Zheng G
Publication: Animal Science Journal, Vol76, Issue 2, April 2005
Read Full Study: Japanese Society of Animal Science

Pharmacokinetics of Theanine Enantiomers in Rats
Published: 2005
Author: Desai, M.J
Publication: Chirality 17:154-162, 2005.
Read Full Study: http://www.ncbi.nlm.nih.gov

Pharmacokinetics of Suntheanine® shown. Poor absorption, unkown safety and efficacy of racemic mixtures confirmed
Published: 2005
Author(s): Desai MJ, Gill MS, Hsu WH, Armstrong DW.
Publication: Chirality 17:154-162, March 2005.
Read Full Study: www.ncbi.nlm.nih.gov

Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level
Published: 2004
Author: Sugiyama, T.
Publication: Cancer Lett., 2004 Aug 30, Vol 212, No. 2, pp 177-84.
Read Full Study: http://www.ncbi.nlm.nih.gov

Effect of Suntheanine® on doxorubicin-induced adverse reaction
Published: 2004
Author: Sugiyama T.
Publication: Proceedings of the AACR, Vol 44, 2nd ed., July 2003
Read Full Study: http://www.ncbi.nlm.nih.gov

Suntheanine® shown to reduce adverse reactions of doxorubicin
Published: 2004
Author: Sugiyama T.
Publication: Cancer Letters, 2004 Aug 30, Vol 212, pp 177-84.
Read Full Study: www.ncbi.nlm.nih.gov

Possible involvement of group I mGluRs in neuroprotective effect of theanine
Published: 2004
Author: Nagasawa, K.
Publication: Biochem. And Biophys. Research Communications 320 (2004) 116-122
Read Full Study: http://www.ncbi.nlm.nih.gov

Possible neuroprotective effect of Suntheanine®
Published: 2004
Author: Nagasawa, K. Biochem. And Biophys.
Publication: Research Communications 320 (2004) 116-122.
Read Full Study: www.ncbi.nlm.nih.gov

Analysis of theanine enantiomers by HPLC/atmospheric pressure ionization-mass spectrometry. Suntheanine® only true L-theanine
Published: 2004
Author: Desai MJ, Armstrong D.W.
Publication: Rapid Commun Mass Spectrom, Vol 18, 2004, pp. 251-6.
Read Full Study: www.ncbi.nlm.nih.gov

Neuroprotective effect of γ-glutamylethylamide (theanine) on cerebral infarction in mice
Published: 2004
Author: Egashira, N.
Publication: Neuroscience Letters, 2004, Vol 363, pp 58-61
Read Full Study: http://www.ncbi.nlm.nih.gov

Neuroprotective effect of Suntheanine® on cerebral infarction
Published: 2004
Author: Egashira, N.
Publication: Neuroscience Letters, 2004, Vol 363, pp 58-61.
Read Full Study: www.ncbi.nlm.nih.gov

Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice
Published: 2004
Author: Zheng, G.
Publication: In Vivo, Vol 18, 2004 Jan. pp 55-62
Read Full Study: http://www.ncbi.nlm.nih.gov

Anti-obesity effects of Sunphenon and Suntheanine®
Published: 2004
Author: Zheng G, Sayama K, Okubo T, Juneja LR, Oguni I.
Publication: In Vivo, Vol 18, 2004 Jan. pp 55-62.
Read Full Study: www.ncbi.nlm.nih.gov

Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry
Published: 2004
Author: Armstrong, D.W.
Publication: Rapid Commun Mass Spectrom, Vol 18, 2004, pp. 251-6
Read Full Study: http://www.ncbi.nlm.nih.gov

Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents
Published: 2003
Author: Sugiyama, T., Sadzuka, Y.
Publication: Biochimica et Biophysica Acta, May 19, 2003
Read Full Study: http://www.ncbi.nlm.nih.gov

Suntheanine® enhances efficacy of chemotherapeutic agents
Published: 2003
Author: Sugiyama T, Sadzuka Y. Biochim
Publication: Biophys Acta. 2003 Dec 5.
Full Story Link: www.ncbi.nlm.nih.gov

Effects of Theanine on the Release of Brain Alpha Wave in Adult Males
Published: 2003
Author: Song, Chan Hee.
Publication: Dept. of Family Medicine, Obesity Clinic, St. Mary’s Hospital, Catholic University of Korea. The Korean Nutrition Society. 2003 36(9): 918-923
Read Full Study: http://www.koreamed.org

Enzymatic production of theanine, an “umami” component of tea, from glutamine and ethylamine with bacterial ϒ– glutamyltranspeptidase
Published: 2003
Author: Suzuki, H.
Publication: Enzyme and Microbial Technology 31 (2002) 884-889
Read Full Study: http://www.ncbi.nlm.nih.gov

Modulation of adipogenesis and lipolysis by green tea (catechins, theanine and caffeine) in 3T3-L1 adipocytes
Published: 2003
Author: Kim, Y.K.
Publication: Pacific R&D Center, Yongin, Korea. Int. Journal of Obesity. Abstracts of the 12th European Congress on Obesity. Helsinki, Finland, 29 May-1 June, 2003
Read Full Study: http://www.ncbi.nlm.nih.gov

Antigens in tea-beverage prime human Vϒ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses
Published: 2003
Author: Kamath, A. Wang, L. Das, H. Li, L. Reinhold, V. Bukowski, J.
Publication: PNAS, Vol. 100, no. 10, 2003 May 13, pp 6009-6014
Read Full Study: http://www.ncbi.nlm.nih.gov

Theanine, γ-glutamylethylamide, is metabolized by renal phosphate-independent glutaminase
Published: 2003
Author: Tsuge, H. Sano, S. Hayakawa, T. Kakuda, T. Unno, T.
Publication: Biochim Biophys Vol 1620, No 1-3, 2003 Mar 17, pp 47-53
Read Full Study: http://www.ncbi.nlm.nih.gov

Neuroprotective effects of the green tea components theanine and catechins
Published: 2002
Author: Kakuda, T.
Publication: Biol Pharm Bull 2002 Dec; 25(12): 1513-8
Read Full Study: http://www.ncbi.nlm.nih.gov

Inhibition by theanine of binding of (3H) AMPA, (3H) kainate, and (3H) MDL 105,519 to glutamate receptors
Published: 2002
Author: Kakuda, T. Nozawa, A. Sugimoto, A. Niino, H.
Publication: Biosci Biotech. Biochem, Vol. 66, No. 12 2002 Dec pp 2683-6
Read Full Study: http://www.ncbi.nlm.nih.gov

Glutamate transporter mediated increase of antitumor activity by theanine, an amino acid in green tea
Published: 2002
Author: Sadzuka, Y, Yamashita, Y, Kishimoto, S, Fukushima, S, Takeuchi, Y, Sonobe, T.
Publication: No. 11 2002 Nov pp. 995-9, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.
Read Full Study: www.ncbi.nlm.nih.gov

Effect of dihydrokainate on the antitumor activity of doxorubicin
Published: 2002
Author: Sadzuka Y, Yamashita Y, Sugiyama T, Sonobe T.
Publication: Cancer Lett. 2002 May 28; 179(2): 157-63
Read Full Study: http://www.ncbi.nlm.nih.gov

The Effects of L-theanine containing Functional Beverage on mental Relaxation and Fatigue Perception
Published: 2002
Author: Song, Chan Hee.
Publication: Department of Family Medicine, Psychiatry, The Catholic University of Korea. Journal Korean Acad Fam Med, Vol. 23, No 5 May, 2002
Read Full Study: http://wprim.whocc.org.cn

Effects of dietary powdered green tea and theanine on tumor growth and endogenous hyperlipidemia in hepatoma-bearing rats
Published: 2002
Author: Zhang G, Miura Y, Yagasaki K.
Publication: Biosci Biotechnol Biochem 2002 Apr;66(4):711-6
Read Full Study: http://www.ncbi.nlm.nih.gov

Improving Effect of Suntheanine® on Premenstrual Syndrome
Published: 2001
Author: Ueda T, Ozeki M, Okubo T, Chu D, Juneja L.R, Yokogoshi H, Matsumoto S.
Publication: Journal of JSPOG Vol. 6, No. 2, pp 234-239, Dec 2001 (Japanese)

Effect of L-Theanine on improvement of sleep
Published: 2001
Author: Shirakawa, Shuichiro.
Publication: National Mental & Nerve Center, JAPAN. Unpublished. December 14, 2001
Read Full Study: Unpublished

Effect of changes of muscle tension and brain alpha wave activity induced by functional beverage on golf performance
Published: 2001
Author: Kim K, Yum K, Lee Y.
Publication: International Symposium on Food, Nutrition and Health, Korean Society of Food Science and Nutrition. Dec 7-8, 2001: 50-51
Read Full Study: https://www.yumpu.com

Effect of brain alpha wave activity and golf performance by Suntheanine®
Published: 2001
Author: Kim K, Yum K, Lee Y.
Publication: Int’l Symposium on Food, Nutrition and Health, Korean Society of Food Science and Nutr. Dec 7-8, 2001: 50-51.

Neuroprotection of γ-glutamylethylamide (theanine) against kainic acid toxicity in rat hippocampus
Published: 2001
Author: Nozawa, A.; Kakuda, T.; Kubo, T.; Tsukamoto, S.
Publication: Society for Neuroscience Abstracts. Vol. 27, No. 1, November 2001, pp 892
Read Full Study: http://eurekamag.com

The sympathomimetic response to a novel ephedra/caffeine based dietary supplement in healthy overweight volunteers
Published: 2001
Author: Krieger D, Kalman D, Sosa D, Schwarts HI, Almada A.
Publication: Journal of The American College of Nutrition, Volume 20, No 5, October 2001, p585

Enhancement of the activity of doxorubicin by inhibition of glutamate transporter
Published: 2001
Author: Sadzuka Y, Sugiyama T, Suzuki T, Sonobe T.
Publication: Tox. Lett. 2001 Sep 15;123(2-3):159-167
Read Full Study: http://www.ncbi.nlm.nih.gov

Correlations between central nervous parameters and hormonal regulations during recovery from physical stress influenced by Suntheanine®
Published: 2001
Author: Weiss M, Schnittker R, Barthel T, Falke W, Juneja L.R.
Publication: Amino Acids (Vienna) 2001 Aug; Vol. 21, No. 1, PP 62.

Scientific study on L-theanine containing drinks with regard on relaxation and regeneration after physical stress as measured by electroencephalography, skin conductance and stress hormones
Published: 2001
Author: Weiss, M.
Publication: Institute for Sports Medicine, University of Paderborn, Germany

EEG changes in humans during regeneration after heavy physical strain with the influence of theanine; amino acid in green tea
Published: 2001
Author: Weiss, M, Schnittker, R, Liesen, H, Juneja, L. R.; Geiss K.R, Barthel, T.
Publication: Amino Acids (Vienna) 2001 August; Vol. 21, No. 1, PP 59
Read Full Study: http://pesquisa.bvsalud.org

Does L-theanine have an influence on relaxation after severe physical exercise? Evaluation using electrosympathicography
Published: 2001
Author: Weiss, M, Reinsberger, C, Liesen, H, Juneja, L. R, Herwegen, H, Geiss, K.R.
Publication: Amino Acids (Vienna) 2001 August; Vol. 21, No. 1, PP 60

Inhibitory effects of theanine and sera from theanine-fed rats on receptor-mediated cancer cell invasion beneath mesothelial cell monolayers
Published: 2001
Author: Zhang G, Miura Y, Yagasaki K.
Publication: Cytotechnology 36: 195-200, 2001
Read Full Study: http://www.ncbi.nlm.nih.gov

Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin
Published: 2001
Author: Sugiyama T, Sadzuka Y, Tanaka K, Sonobe T.
Publication: Tox Lett 2001 Apr 30;121(2):89-96
Read Full Study: http://www.ncbi.nlm.nih.gov

Suntheanine® shown to enhance the therapeutic efficacy of doxorubicin
Published: 2001
Author: Sugiyama T, Sadzuka Y, Tanaka K, Sonobe T.Tox
Publication: Lett 2001 Apr 30;121(2):89-96.
Full Story Link: www.ncbi.nlm.nih.gov

Neuroprotection of γ-glutamylethylamide (theanine) in middle cerebral artery occlusion in the rat
Published: 2000
Author: Kakuda, T.
Publication: Society for Neuroscience Abstracts. Vol. 26, No. 1-2, 2000 pp 183.19
Read Full Study: http://eurekamag.com

Improvement of idarubicin induced antitumor activity and bone marrow suppression by theanine, a component of tea
Published: 2000
Author: Sadzuka Y, Sugiyama T, Sonobe T.
Publication: Cancer Lett 2000 Oct 1;158(2):119-124
Read Full Study: http://www.ncbi.nlm.nih.gov

Effect of Theanine, r-glutamylethylamide, on Brain Monoamines, striatal dopamine release and some kinds of behavior in rats
Published: 2000
Author: Yokogoshi H, Terashima T.
Publication: Nutrition 2000, Sep; 16(9):776-777.
Read Full Study: www.ncbi.nlm.nih.gov

Protective effect of γ-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils
Published: 2000
Author: Kakuda, T.
Publication: Neuroscience Letters. Vol. 289, No. 3, August 11, 2000. pp 189-192
Read Full Study: http://www.ncbi.nlm.nih.gov

Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multi-drug resistance
Published: 2000
Author: Sadzuka Y.
Publication: Toxicol Lett. 2000 Apr 3;114(1-3):155-62.
Read Full Study: www.ncbi.nlm.nih.gov

Theanine, a major amino acid of green tea, enhances antitumor activity of doxorubicin via inhibition of glutamate transporter
Published: 2000
Author: Sugiyama, T.
Publication: Proceedings of the American Association for Cancer Research Annual. March 2000. No 41, p. 242
Read Full Study: http://www.ncbi.nlm.nih.gov

Liver injury-preventive effect of tea theanine in rats
Published: 2000
Author: Sugiyama, K.
Publication: Journal of Food Science. Jan.-Feb. 2000. Vol. 65, No. 1, p. 30-33
Read Full Study: Journal of Food Science

Inhibiting effects of theanine on caffeine stimulation evaluated by EEG in the rat
Published: 2000
Author: Kakuda T.
Publication: Biosci Biotech. Biochem 2000 Feb;64(2):287-93
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Effect of Suntheanine® Intake on Learning Ability of Rats
Published: 1999
Author: Terashima T.
Publication: Fourth Shizuoka Forum on Health and Longevity. Nov 18, 1999 p.82-83.

Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity
Published: 1999
Author: Bukowski J.F.
Publication: Immunity. 1999 Jul;11(1):57-65
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Membrane transport and antitumor activity of pirarubicin, and comparison with those of doxorubicin
Published: 1999
Author: Sugiyama T.
Publication: Jpn J Cancer Res. 1999 Jul;90(7):775-80
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L-theanine – Unique amino acid of green tea and its relaxation effect in humans
Published: 1999
Author: Juneja LR
Publication: Trends in Food Sci. Tech. June 1999. v10 (6/7) p. 199-204.
Read Full Study: www.sciencedirect.com

Protective effect of theanine on ischemic neuronal death in transient forebrain ischemia model
Published: 1999
Author: Unno T.
Publication: Society for Neuroscience Abstracts. 1999, Vol. 25, No. 1-2, p. 575
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Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administered with theanine
Published: 1999
Author: Terashima T.
Publication: Biosci Biotechnol Biochem. 1999 Apr;63(4):615-8
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Metabolism of theanine, small γ-glutamylethylamide, in rats.
Published: 1999
Author: Unno T.
Publication: Journal of Ag and Food Chem. April 1999, v.47, No 4 pp 1593-96
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Theanine, a major amino acid in green tea, inhibits severe leukopenia and enhances antitumor activity induced by idarubicin
Published: 1999
Author: Sugiyama T.
Publication: Proc. American. Assoc. Cancer Research. 40, March 1999
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Combination of theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma
Published: 1999
Author: Sugiyama T.
Publication: Clin Cancer Res 1999 Feb:413-6
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Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma
Published: 1998
Author: Sugiyama T.
Publication: Cancer Lett. 1998 Nov 13;133(1):19-26
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Hypotensive effect of γ-glutamylmethylamide in spontaneously hypertensive rats
Published: 1998
Author: Yokogoshi, H.
Publication: Life Sci. 1998;62(12):1065-8.
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Green tea component, theanine enhances the antitumor activity of adriamycin against sensitive P388 leukemia and resistant P388-ADR
Published: 1998
Author: Sugiyama, T.
Publication: Proceedings of the American Association for Cancer Research Annual Meeting. 1998, Vol. 39, p. 528
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Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats
Published: 1998
Author: Yokogoshi, H.
Publication: Neurochem Res. 1998 May;23(5):667-73.
Full Story Link: www.ncbi.nlm.nih.gov

Suntheanine® induced reduction of brain serotonin
Published: 1998
Authors: Yokogoshi H
Publication: Biosci Biotechnol Biochem. 1998 Apr;62(4):816-7.
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Theanine-induced reduction of brain serotonin concentration in rats
Published: 1998
Author: Yokogoshi H.
Publication: Biosci Biotechnol Biochem. 1998 Apr;62(4):816-7
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Theanine, a major flavorous amino acid in green tea leaves, inhibits glutamate-induced neurotoxicity on cultured rat cerebral corticalneurons
Published: 1998
Author: Nozawa, A.
Publication: Society for Neuroscience Abstracts. 1998, Vol. 24, No. 1-2, p. 978

Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats
Published: 1998
Author: Yokogoshi, H.
Publication: Life Sci. 1998;62(12):1065-8
Read Full Study: http://www.ncbi.nlm.nih.gov

Modulation of cancer chemotherapy by green tea
Published: 1998
Author: Sadzuka Y.
Publication: Clin Cancer Res. 1998 Jan;4(1):153-6
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Influence of green tea and its three major components upon low-density lipoprotein oxidation
Published: 1997
Author: Yokozawa, T.
Publication: Exp Toxicol Pathol. 1997 Dec;49(5):329-35
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Chewing-gum flavor affects measures of global complexity of multichannel EEG
Published: 1997
Author: Yagyu, T.
Publication: Neuropsychobiology. 1997;35(1):46-50
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Inhibitory effect of green tea on injury to cultured renal epithelial cell line, LLC-PK1
Published: 1997
Author: Yokozawa T.
Publication: Biosci Biotech. Biochem. 1997 Jan;61(1):204-6
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Transmural potential changes associated with the in vitro absorption of theanine in the guinea pig intestine
Published: 1996
Author: Kitaoka, S.
Publication: Biosci Biotech. Biochem. 1996 Nov;60(11):1768-71
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The effects of theanine, as a novel biochemical modulator, on the antitumor activity of adriamycin
Published: 1996
Author: Sadzuka, Y.
Publication: Cancer Lett. 1996 Aug 2;105(2):203-9
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Effects of a component of green tea on the proliferation of vascular smooth muscle cells
Published: 1995
Author: Yokozawa, T.
Publication: Biosci Biotech. Biochem. 1995 Nov;59(11):2134-6
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Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats
Published: 1995
Author: Yokogoshi, H.
Publication: Biosci Biotech. Biochem. 1995 Apr;59(4):615-8
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Theanine, a glutamate analog, stimulates NMDA-receptors by suppresses excitatory effect of caffeine in cortical neurons
Published: 1995
Author: Nozawa, A.
Publication: Society for Neuroscience Abstracts. 1995, Vol. 21, No. 1-3, p. 835
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Pharmacological effect of theanine
Published: 1992
Author: Sagesaka, Y.
Publication: Proceedings of the International Symposium on Tea Science, August 26-29, 1991, 362-364
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Green tea composition, consumption, and polyphenol chemistry
Published: 1992
Author: Graham, H.N.
Publication: Prev Med. 1992 May;21(3):334-50
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Metabolism of L-theanine in tea leaves
Published: 1987
Author: Tsushida, T.
Publication: JARQ (Japan Agricultural Research Quarterly. 1987, Vol. 21, No. 1, p 42-46
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Effect of Suntheanine® on norepinephrine and serotonin levels
Published: 1986
Author: Kimura R
Publication: Chem Pharm Bull (Tokyo). 1986 Jul;34(7):3053-7.
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Effect of theanine on norepinephrine and serotonin levels in rat brain
Published: 1986
Author: Kimura, R.
Publication: Chem Pharm Bull (Tokyo). 1986 Jul;34(7):3053-7
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Investigation of the presence and significance of theanine in the tea plant
Published: 1986
Author: Feldheim, W.
Publication: Journal of the Science of Food and Agriculture. 1986, Vol. 37, No. 6, p. 527-534
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Synthesis and antibacterial activities of theanine-containing oligopeptides
Published: 1980
Author: Oda, Y.
Publication: Chem Pharm Bull (Tokyo). 1980 Dec;28(12):3549-54
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Influence of alkylamides of glutamic acid and related compounds on the central nervous system. IV. Effect of theanine on adenosine 3′,5′-monophosphate formation in rat cerebral cortex
Published: 1980
Author: Kimura, R.
Publication: Chem Pharm Bull (Tokyo). 1980 Feb;28(2):664-6
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Theanine as a glutamate antagonist at a crayfish neuromuscular junction
Published: 1978
Author: Shinozaki, H.
Publication: Brain Res. 1978 Jul 28;151(1):215-9
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Influence of alkylamides of glutamic acid and related compounds on the central nervous system. III. Effect of theanine on spontaneous activity of mice
Published: 1975
Author: Kimura, R.
Publication: Yakugaku Zasshi. 1975 Jul;95(7):892-5. Japanese
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Influence of alkylamides of glutamic acid and related compounds on the central nervous system. II. Synthesis of Amides of Glutamic Acid and Related Compounds, and their Effects on the Central Nervous System
Published: 1971
Author: Kimura, R.
Publication: Chem Pharm Bull (Tokyo). 1971 Vol. 19 No. 7, 1301 – 1307
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Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine
Published: 1971
Author: Kimura, R.
Publication: Chem Pharm Bull (Tokyo). 1971 Jun;19(6):1257-61
Read Full Study: http://www.ncbi.nlm.nih.gov